A number of factors influence the longevity of the insertion site. The precipitate was observed to be of crystalline and transparent in nature, and was identified as being haloperidol following HPLC analysis. Allwood[ 16 ] also investigated the compatibility and stability of diamorphine hydrochloride in combination with haloperidol over a period of 45 days. Good et al; ; Australia [ 13 ] Midazolam hydrochloride 2. Similar documentation is recommended for patients who are receiving care at home. American Society of Health System Pharmacists; What is a syringe driver?

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Although medicines can also be administered by other routes, such as rectal or sublingual, a further advantage of a continuous subcutaneous infusion is that any peaks and troughs of intermittent delivery methods are avoided Table 1.

Hyoscine- N -butylbromide, haloperidol, diamorphine and fentanyl appear to be physicochemically stable at concentrations investigated in the articles included in this review and are broadly comparable to those encountered in hour CSCIs in the UK[ 11 ]. Journal of Pharmaceutical Analysis.

Watson et al; ; UK [ 32 ]. Destro et al also investigated physical compatibility between binary mixtures of morphine hydrochloride with diclofenac sodium, methadone hydrochloride with ketoralac tromethamine, and methadone hydrochloride with diclofenac sodium.

When and how to use a syringe driver in palliative care

Selection of the infusion site Plastic cannulae are recommended, although metal butterfly needles can be used. Barcia et al; ; Spain [ 18 ]. The authors have declared that no competing interests exist. Initially the preferred replacement option was the AD Ambulatory Syringe Driver, however, syringr company involved was unable to supply and support these drivers and a further decision was made so that by 30 June,the Niki T34 syringe driver was used exclusively. Register to use all the features of this website, including selecting clinical areas of interest, taking part in quizzes and much more.



The lockable, battery operated, Niki T34 syringe driver is the current device available in New Zealand for the continuous halopwridol administration of medicines in a community setting. Grassby PF, Hutchings L. More stability data is required before the use of hour CSCIs can be evaluated for use within clinical practice.

Diamorphine hydrochloride and haloperidol Allwood[ 16 ] investigated the compatibility and stability of diamorphine hydrochloride in combination with haloperidol over a ayringe of 45 days.

If problems arise with an infusion site the patient may have localised discomfort, or there may be reduced absorption of the medicine and a loss of symptom control. Open in a separate window. Compatibility of haloperidol and hyoscine-N-butyl bromide in mixtures for subcutaneous infusion to cancer patients in palliative care.

Plastic cannulae are recommended, although metal butterfly needles can be used. Abstract Background A continuous subcutaneous infusion CSCI is an effective method of multiple drug administration commonly encountered in end of life care when the oral route is compromised.

However, the administration device and syringe haloperidool situ may still need to be checked e.

Some of the practical issues that may need to be addressed include: Received Aug 23; Accepted Feb Can J Hosp Pharm.

Hospice New Zealand; Many patients will also anv under the care of a palliative care physician. HPLC analysis of all solutions showed no clinically significant loss of hyoscine- N -butylbromide or haloperidol throughout the duration of investigation. This meant that the searches performed should have been broad enough to identify much of papers available; further to this the bibliographies of included articles were reviewed to identify znd articles missed during the search of the electronic databases.


HPLC-DAD methods for studying the stability of solutions containing hydromorphone, ketorolac, haloperidol, midazolam, famotidine, metoclopramide, dimenhydrinate, and scopolamine.

BPJ When and how to use a syringe driver in palliative care

The administration of drugs by subcutaneous infusion is routinely practiced in palliative medicine for morphkne management of patients who are no longer able to take oral medication. However, the ability to deliver prescribed medication by a CSCI over 48 hours may have numerous benefits in both patient care and health service resource utilisation.

Monitoring the infusion Patients being cared for at home should ideally have a daily visit from a health professional for review of symptom control and monitoring of the infusion.

Stability and compatibility of binary mixtures of morphine hydrochloride with hyoscine-n-butyl bromide. Negro et al; ; Spain [ 29 ]. Negro et al; ; Spain [ 28 ].

All studies also tested the pH of samples both pre- and post- the analytical period to observe for any variation in addition to the HPLC testing. This review aimed to evaluate the current evidence base to support increasing CSCI infusion times above the current maximum of 24 hours. With guidance and support from the local hospice or district nursing services, General Practitioners can arrange a syringe driver infusion for a patient in their home or in a residential care facility, prescribe and monitor the appropriate mix of medicines and manage breakthrough symptoms.